Datasets from Clinical Studies

NIH-Supported Data for Secondary Analysis

Participant data from clinical trials and observational studies funded by the National Institutes of Health (NIH) are available for qualified investigators to use in secondary data analysis.

Central Data Repositories

NIH institutes maintain central repositories that store health and human data collected by NIH-supported research projects. These repositories share data independently of each project’s own data-sharing program, which can often be difficult to access.

Access Requirements:

• A Login.gov account tied to your institutional email (free to create)

Available Repositories:

• National Heart, Lung, and Blood Institute (NHLBI)

  Includes major cardiovascular studies such as:

• Framingham Heart Study

• Multi-Ethnic Study of Atherosclerosis

• Atherosclerosis Risk in Communities

  Access via BioLINCC (Biologic Specimen and Data Repository Information Coordinating Center)

  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

• Includes studies like the Diabetes Prevention Program

• Access via NIDDK Central Repository

• National Eye Institute (NEI)

• Access via NEI Data Commons

• National Cancer Institute (NCI)

• Access via Cancer Research Data Commons

• National Institute on Alcohol Abuse and Alcoholism (NIAAA) and National Institute of Mental Health (NIMH)

• Access via NIMH Data Archive

Database of Genotypes and Phenotypes (dbGaP)

dbGaP is a database of -omics data paired with clinical data to support systems biology research. Examples include:

• Whole-genome sequencing

• Metabolomics

• Proteomics

• Transcriptomics

Key Features:

• Data often originates from stored biospecimens from large, population-based studies

• Approval from both the parent study and dbGaP is typically required

• Parent studies can be identified in the Central Data Repositories section

  Learn more about dbGaP