All of Us and N3C

About All of Us and N3C Program

The The All of Us Research Program, organized by the National Institutes of Health (NIH), is a prospective, multi-center observational study. Its goal is to create a central repository of data from multiple domains for secondary research, including:

• Physical examinations

• Surveys

• Electronic health records

• Genomic and other -omic data

Support Services

• Supports genome-wide and related association studies

• As of 2025:

• 600,000 participants have contributed data

• 300,000 participants have linked EHR information

• Access requires:

• Completion of online training modules

• Verification of investigator credentials

• New users receive a quota of free compute time, generally sufficient for analyses that do not involve -omic data

National COVID Cohort Collaborative (N3C)

The N3C is a collaboration among Clinical and Translational Science Awards (CTSA) Program hubs, supported by the National Center for Advancing Translational Science (NCATS), along with distributed clinical data networks such as:

• PCORnet

• OHDSI

• ACT

• TriNetX

Provides Support

• Improve efficiency and accessibility of COVID-19 clinical data analysis

• Enhance understanding of COVID-19

• Demonstrate a novel model for collaborative data sharing